Claudio Agustino
Faculty of Medicine University of Indonesia , Indonesia
Title: Comparison between Albumin, Prothrombin Time, and Fibrinogen Profile in Staging of Liver Cirrhosis based on APRI Score Classification
Biography
Biography: Claudio Agustino
Abstract
Cirrhosis is an end stage of chronic inflammatory disease with the destruction of liver tissue and
fibrosis that impairs its function to synthesis albumin, prothrombin, and fibrinogen. Cirrhosis can be
detected and classified into 3 groups with non-invasive diagnostic technique by using APRI score.
This study aims to find out the significant difference between albumin, prothrombin time, and
fibrinogen profile within cirrhosis stages based on classification from APRI score. Design of the
study is cross sectional with 60 patients which meet the criteria from the medical records in the
Clinical Pathology Laboratory and center of medical record of RSCM.: The results of the study
were analyzed with Kolmogorov Smirnov test showed albumin level, prothrombin time, and
fibrinogen (median 2.91, 11.8, and mean 273.7117) , Anova or Kruskal Wallis test showed
significant difference between these three components based on score APRI classification. ( all
p<0.05).Then, Post hoc test (Bonferroni for Anova, Mann Whitney for Kruskal Wallis) of
albumin’s profile showed significant difference for comparison between group APRI score less than
0.5 and more than 2. Post hoc test of prothrombin time showed significant difference from all
comparisons. Post hoc test of fibrinogen profile showed significant difference from comparison
between group APRI less than 0.5 and more than 2 ; APRI less 0.5 – 2 and more than 2. As a
results, there are significant difference from comparison between albumin, prothrombin time, and
fibrinogen profile in staging of liver cirrhosis based on classification from APRI score.