Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Ishank Goel

Ishank Goel

Datta Meghe Institute of Medical Sciences, India

Title: Hepatic involvement in Dengue in children- An ominous sign

Biography

Biography: Ishank Goel

Abstract

This cross sectional observational study was done in the paediatric wards and ICU of Acharya Vinoba Bhave Rural Hospital, Sawangi, Wardha, Maharashtra, Central India. In our study, children below 16 years with serology positive dengue fever were included. The dengue score formulated in our institute which was pre-designed and pre-validated was used to grade these children according to symptomatology. A score of >20 out of 30 indicated a poor prognosis, 11-19 indicated good prognosis (with some morbidities) and a score of 0-10 indicated excellent prognosis. Outcome was measured in terms of death, ventilatory support, encephalitis, need for transfusion of blood products, shock, prolonged mean duration of stay. In our study, out of the 120 tested patients, 50 children with dengue serology positive were further graded according to their presenting symptoms like tachypnea (4), urine output (4), deranged LFTs (4), hypotension (4), pulse pressure (3), convulsions (3), capillary leak (2), platelet count (2), heart rate (2), fever (1) and rash (1). We found that 42 out of the 50 (84%) had hepatic involvement in the form of deranged LFTs or organomegaly and the remaining 8 had no hepatic involvement. Out of the 42, liver involvement was seen as follows: raised alanine transaminase (ALT) (80.9%), raised aspartate aminotransferase (AST) (71.4%), hepatomegaly (66.7%), reduced serum albumin (59.5%), raised alkaline phosphatase (42.8%) and prolonged prothrombin time (PT) (30.9%). We found that hepatic involvement had a statistically significant association with poor outcome in patients of dengue (along with other markers like tachypnea, urine output and hypotension).